Application of peristaltic pump in tangential flow filtration

2022-05-10

Today I will take you to understand the application of a Peristaltic Pump in tangential flow filtration:
With the gradual formation of the new scientific revolution led by life science and biotechnology, the wave of biotechnology centered on medical biotechnology is developing in-depth. At the same time, the development of biomedical technology promotes the rise of a new industry - the biomedical industry. The biomedical industry involves modern medical fields such as disease prevention, disease diagnosis, biotechnology drugs, biological therapy, and regenerative medicine, and has become the high-tech industry with the best market prospect in the current biological industry.
Separation and purification technology is the core of the biopharmaceutical process. To produce high purity and high activity biological drugs, the traditional separation, and purification technology can not solve the technological needs of modern biopharmaceutical enterprises. Due to the diversity of biological drug structures and the increasingly strict requirements of the regulatory authorities on the purity of biological drugs, the biological pharmaceutical process is very strict and stringent requirements on materials, making the separation and purification of biological drugs more and more difficult. Therefore, how concentrating, separating, and purifying target biomolecules from complex components economically and efficiently is often the bottleneck of biological drug production.
Tangential flow filtration is an important process step in the biopharmaceutical process. In recent years, with the increasing concentration requirements of some injection products (monoclonal antibodies, vaccines, recombinant proteins, blood products, etc.), the production cost and operation difficulty are also increasing gradually. Tangential flow filtration is necessary for large-scale material and liquid filtration, which is beneficial to reducing the overall cost and making the realization of high concentration technology possible.
Tangential flow filtration is one of the pressure filtration/membrane filtration technologies. In the traditional dead-end filtration technology, the flow direction of the filtrate is perpendicular to the filtration membrane and consistent with the filtration direction. Most of the small molecules pass through the filtration membrane, while the large molecules gather on the surface of the membrane. With the increase of time, the particles accumulated on the membrane surface also increase the filtration resistance increases, and the membrane permeability rate decrease.
In tangential flow filtration, the flow direction of the filtrate is parallel to the filtration membrane and vertical to the filtration direction. A small part of small molecules pass through the filtration membrane, and large molecules are taken away from the membrane surface. With the increase of time, the number of particles accumulated on the membrane surface is limited, which does not affect the speed and effect of filtration.
Tangential flow filtration is commonly used in the production of biological products, blood products, and vaccines.
Advantages of peristaltic pump in tangential flow filtration application:
1. Peristaltic pump has low shear force, which can ensure the integrity and activity of biomolecules when pumping biological active substances.
2. Peristaltic pump is simple and convenient to replace the hose. In the laboratory, when transmitting different solutions, the cross pollution between different solutions can be avoided by simply replacing the hose that meets the hygiene level.
3. The flow can be manually adjusted or automatically adjusted by receiving the control signal from the external controller to ensure that the system pressure is within the allowable range.
4. Accurate and controllable flow can maintain the continuous filtration of a tangential flow filtration system to achieve the desired concentration effect.
5, The use of a Pharmed tube, good corrosion resistance, good wear resistance, and the hose service life is more than 10 000 hours, in the transmission of a high-value solution, can reduce the leakage loss caused by hose damage to the greatest extent.
If you are interested in the peristaltic pump or have any questions, please leave a message or contact us: www.crpump.com,support@crpump.com,15633705132

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